Medication

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Disclaimer: This website was designed as part of a diploma project at the Medical University of Vienna. All content displayed on this website is for research purposes only and was created with the greatest possible care, nevertheless no responsibility can be taken for this information or any content provided by links from external sources. For more information click here.

Important notice: The following list provides guiding principles for drug prescription in patients with chronic kidney disease only. Do not prescribe or take medication based on this list!

For more detailed information about the data source click here.

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This site provides an overview of most prescribed drugs sorted by primary indication.

Drugs are classified into three categories: “No dosage adaption necessary”, “Adapt dosage in case of decreased renal function” and “Caution in case of decreased renal function.”

It has to be considered that classification done as part of the diploma project provides only a limited view on drug prescription in patients with chronic kidney disease. Many drugs categorized as “No dosage adaption necessary” are able to generate toxic metabolits for to the kidney and should be handled carefully and with the same procedures as drugs categorized as “Caution in case of decreased renal function.” in case of patients with stage 4 and 5 chronic kidney disease.

When prescribing drugs categorized as “Adapt dosage in case of decreased renal function” or “Caution in case of decreased renal function”, patients should be monitored and clinical situation taken in consideration. These drugs are often contraindicated in patients with stage 4 and 5 chronic kidney disease.

Alternative drugs are displayed if other drugs rated as “No dosage adaption necessary” from the same category are available. Please consider though that these drugs may have a different effect mechanism which could be not appropriate for your intented use.

Drugs selection was based on the “Arzneimittelreport 2012” which provides an overview of the most prescribed drugs in Germany categorized by their primary use into 31 groups [1]. To assign drugs to the correct state thoroughly literature research was conducted. State of the art text books, manufacturers information and internet resources were used as a source [2][3][4]. Please refer to the soon to be published diploma project for an in depth description of methods used [5].

[1] Ulrich Schwabe and Dieter Paffrath. Report 2012. 2012, p. 38. isbn:9789251074008. doi: 10.2853/54866.

[2] Michael Freissmuth and Stefan Offermanns. Pharmakologie und Toxikologie: Von den molekularen Grundlagen zur Pharmakotherapie. 2016.

[3] DOSING. url: http://dosing.de/ (visited on 01/12/2017).

[4] PharmaWiki. url: http://www.pharmawiki.ch/wiki/index.php?wiki=PharmaWiki (visited on 02/02/2017)

[5] H Kerschbaumer. Decision support solutions for improving drug safety in patients with chronic kidney disease. Not published yet.

Quick Guide: Enter your GFR (Global Filtration Rate) in the textfield. If unkown use the link to the online calculator below. Information for specific drugs are color coded.

Green texts indicates that no specific action is necessary.

Orange texts indicates that further measures might have to be taken.

Red texts indicates that you should avoid this drug or thoroughly provide medical indication.

Use the search box to quickly find specific drugs.

Stage Description GFR (ml/min/1.73 m2)
1 Kidney damage with normal or increased GFR >=90
2 Kidney damage with mild reduced GFR 60-89
3a Mild to moderate reduced GFR 45-59
3b Moderate to severe reduced GFR 30-44
4 Severe reduced GFR 15-29
5 Kidney failure <15 (or dialysis)

Click here for using an online calculator provided by https://www.kidney.org

Analgetics

Angiotensin receptor blocker

Antiasthmatics

Antibiotics

Antidiabetics

Antiphlogistics

Beta blockers

Antihypertensives

Calcium antagonists

Diuretics

Antiepileptics

Antigout preparations

Cardiac therapy

Antihistamins

Laxatives

Antilipemics

Muscle relaxants

Opthalmologicals

Osteoporotic therapy

Psychotropic drugs

Nasal preparations

Sex hormones

Steroids

Antithrombotic therapy

Thyroid therapy

Tussis

Urologicals

Antivertiginous therapy

Vitamins

Anti-Parkinson drugs